Positive regulation of cell growth involved in cardiac muscle cell development

Across TCGA cell cohorts, RNA activity of the Positive regulation of cell growth involved in cardiac muscle cell development pathway is significantly associated with the shRNA dependency of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MUC5B, KIRREL3, and ACOT12, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MUC5B grouped by Positive regulation of cell growth involved in cardiac muscle cell development-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	MUC5B →	-0.286	-1.823	.003	<.001	3	4
KIDNEY	KIRREL3 →	+0.160	+1.324	<.001	.001	3	4
LUNG_NSCLC_LUSC	ACOT12 →	-0.167	-1.299	<.001	.001	3	3
LUNG_NSCLC_LUSC	DDX28 →	+0.188	+1.887	.007	<.001	3	3
UPPER_AERODIGESTIVE_TRACT	RPRD1A →	+0.116	+1.529	.006	<.001	3	3
LIVER	KLHL2 →	+0.224	+1.446	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MUC5B by Positive regulation of cell growth involved in cardiac muscle cell development activity — STOMACH

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