Positive regulation of cell growth involved in cardiac muscle cell development

Across TCGA cell cohorts, RNA activity of the Positive regulation of cell growth involved in cardiac muscle cell development pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EDN1, THBS1, and C4BPB, each associated with the pathway in up to 15 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of cell growth involved in cardiac muscle cell development activity versus EDN1 in KIDNEY (Pearson r = 0.89).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	EDN1 →	+3.921	+1.766	<.001	<.001	3	15
URINARY_TRACT	THBS1 →	+3.742	+1.228	.001	.007	2	8
LARGE_INTESTINE	C4BPB →	+1.504	+0.546	.005	.007	3	7
KIDNEY	HBEGF →	+2.375	+1.404	<.001	<.001	3	6
URINARY_TRACT	ANKRD1 →	+4.836	+1.896	<.001	<.001	3	6
LARGE_INTESTINE	FAM151B →	-0.518	-0.778	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061051 vs EDN1 — KIDNEY

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