Regulation of cell growth involved in cardiac muscle cell development

Across TCGA patient cohorts, RNA activity of the Regulation of cell growth involved in cardiac muscle cell development pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TYMS, LINC02613, and TXNL4A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cell growth involved in cardiac muscle cell development activity versus TYMS in LSCC (Pearson r = 0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TYMS →	+0.580	+0.211	<.001	.001	3	4
CCRCC	LINC02613 →	+0.127	+0.372	.004	.003	3	3
OV	TXNL4A →	+0.641	+0.148	<.001	.007	3	3
OV	SEC11C →	+0.664	+0.161	.001	.002	3	3
OV	CDCA4 →	+0.778	+0.175	.002	.001	3	3
LUAD	CDKN3 →	+0.792	+0.177	.003	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061050 vs TYMS — LSCC

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