Regulation of cell growth involved in cardiac muscle cell development

Across TCGA cell cohorts, RNA activity of the Regulation of cell growth involved in cardiac muscle cell development pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GPN2, SLC9A8, and C1RL, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GPN2 grouped by Regulation of cell growth involved in cardiac muscle cell development-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	GPN2 →	-0.659	-1.107	<.001	<.001	3	4
SOFT_TISSUE	SLC9A8 →	-0.929	-0.978	<.001	.004	3	4
LIVER	C1RL →	-1.233	-1.480	.002	.002	3	3
LUNG_NSCLC_LUAD	IGFN1 →	-0.944	-0.514	.005	.002	3	3
LUNG_SCLC	GSR →	+1.187	+0.734	.002	.007	3	3
STOMACH	TXNDC12 →	-0.538	-0.531	.003	.007	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GPN2 by Regulation of cell growth involved in cardiac muscle cell development activity — SOFT_TISSUE

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