Regulation of branching involved in lung morphogenesis

pathway activity — cross-omics
GO:0061046Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Regulation of branching involved in lung morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PTK7, PLOD3, and PSMB10, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
BRCAPTK7 →+0.552+0.053<.001.00136
LSCCPLOD3 →+0.388+0.068.001.00436
GBMPSMB10 →-0.464-0.093<.001.00236
UCECHIP1 →+0.282+0.093.001<.00136
PDACEFEMP2 →+0.590+0.104.002<.00136
HNSCDENND2D →-0.250-0.060.001<.00135
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration