Negative regulation of wound healing

Across TCGA cell cohorts, RNA activity of the Negative regulation of wound healing pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CACNA1C, PTEN, and NTN1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CACNA1C grouped by Negative regulation of wound healing-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	CACNA1C →	-0.363	-1.492	.004	.001	3	5
KIDNEY	PTEN →	-0.261	-0.981	.002	<.001	3	5
OVARY	NTN1 →	-0.167	-0.676	.006	.001	3	4
CNS	GCSHP3 →	-0.245	-0.892	.001	<.001	3	4
BLOOD_Leukemia	TAAR9 →	-0.220	-1.151	<.001	.004	3	4
SKIN	HERC1 →	-0.125	-1.061	<.001	<.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CACNA1C by Negative regulation of wound healing activity — BLOOD_Lymphoma

Explore this box plot interactively →