Negative regulation of wound healing

Across TCGA cell cohorts, RNA activity of the Negative regulation of wound healing pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BBOX1, P2RX7, and PRDM2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, BBOX1 grouped by Negative regulation of wound healing-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	BBOX1 →	+0.131	+0.108	<.001	<.001	3	5
LUNG_SCLC	P2RX7 →	+0.281	+0.096	<.001	.004	3	5
URINARY_TRACT	PRDM2 →	+0.305	+0.167	.001	.001	3	5
LUNG_SCLC	ZBTB45 →	-0.211	-0.123	.004	.001	3	5
LUNG_SCLC	PPP3R2 →	+0.228	+0.138	<.001	<.001	3	5
BONE	STRN4 →	-0.510	-0.168	.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BBOX1 by Negative regulation of wound healing activity — BREAST

Explore this box plot interactively →