Regulation of vascular wound healing

Across TCGA patient cohorts, RNA activity of the Regulation of vascular wound healing pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MS4A8, ENPP7P11, and LRRC31, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of vascular wound healing activity versus MS4A8 in PDAC (Pearson r = 0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	MS4A8 →	+1.009	+0.501	<.001	<.001	3	4
BRCA	ENPP7P11 →	+0.841	+0.329	.005	.006	3	4
PDAC	LRRC31 →	+0.833	+0.420	<.001	.004	3	3
HNSC	ECHDC2 →	+0.541	+0.624	.001	.001	3	3
PDAC	ASL →	+0.371	+0.568	.006	.009	3	3
HNSC	HNF4G →	+0.666	+0.768	.009	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061043 vs MS4A8 — PDAC

Explore this scatter interactively →