Vascular wound healing

Across TCGA patient cohorts, RNA activity of the Vascular wound healing pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PRKG1, CD248, and HSPA12B, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vascular wound healing activity versus PRKG1 in UCEC (Pearson r = 0.49).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PRKG1 →	+0.617	+0.079	<.001	<.001	3	10
OV	CD248 →	+0.814	+0.060	<.001	<.001	3	9
BRCA	HSPA12B →	+0.427	+0.034	.001	.001	3	9
GBM	STAB1 →	+0.687	+0.087	<.001	<.001	3	8
UCEC	CAVIN1_S175 →	+1.069	+0.072	.002	.001	3	8
UCEC	CD93 →	+0.344	+0.080	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061042 vs PRKG1 — UCEC

Explore this scatter interactively →