Vascular wound healing

Across TCGA patient cohorts, RNA activity of the Vascular wound healing pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SH3BGRL2, SLC12A2, and MECOM, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vascular wound healing activity versus SH3BGRL2 in HNSC (Pearson r = 0.06).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SH3BGRL2 →	+1.282	+0.690	<.001	.002	3	4
HNSC	SLC12A2 →	+0.821	+0.633	<.001	.001	3	4
HNSC	MECOM →	+0.811	+0.720	.003	.001	3	4
COAD	PARM1 →	+0.599	+0.474	.001	<.001	3	4
CCRCC	DEPP1 →	+0.834	+0.626	.001	.005	3	4
PDAC	KCNE3 →	+0.717	+0.536	.003	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061042 vs SH3BGRL2 — HNSC

Explore this scatter interactively →