Vascular wound healing

Across TCGA cell cohorts, RNA activity of the Vascular wound healing pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VEGFA, CXCR4, and XBP1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, VEGFA grouped by Vascular wound healing-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	VEGFA →	-0.308	-0.347	.004	.001	3	7
CNS	CXCR4 →	-0.188	-0.653	.002	.007	2	8
BREAST	XBP1 →	-0.257	-0.790	<.001	<.001	3	6
LIVER	MIR200B →	-0.603	-1.394	.005	.001	3	6
LUNG_NSCLC_LUAD	FZD4 →	-0.255	-0.893	<.001	.001	3	5
LUNG_NSCLC_LUAD	NSUN2 →	-0.145	-0.618	.003	.008	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

VEGFA by Vascular wound healing activity — LUNG_SCLC

Explore this box plot interactively →