Vascular wound healing

Across TCGA cell cohorts, RNA activity of the Vascular wound healing pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MFSD9, FAM71E1, and FOSL2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MFSD9 grouped by Vascular wound healing-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	MFSD9 →	+0.982	+0.552	.004	.006	3	5
KIDNEY	FAM71E1 →	+1.010	+1.927	<.001	<.001	3	4
SOFT_TISSUE	FOSL2 →	-2.120	-1.776	<.001	<.001	3	4
OESOPHAGUS	PDCD6 →	-0.924	-1.395	.006	.005	3	4
LARGE_INTESTINE	NDUFS6 →	-0.623	-1.274	<.001	<.001	3	4
LUNG_SCLC	RAB28 →	+0.691	+0.528	<.001	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MFSD9 by Vascular wound healing activity — LUNG_SCLC

Explore this box plot interactively →