Vascular wound healing

Across TCGA cell cohorts, RNA activity of the Vascular wound healing pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CLEC3B, NF1, and APBB1IP, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CLEC3B grouped by Vascular wound healing-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	CLEC3B →	-0.282	-1.588	<.001	<.001	3	3
LUNG_NSCLC_LUAD	NF1 →	-0.376	-1.677	.001	<.001	3	2
LUNG_NSCLC_LUAD	APBB1IP →	+0.225	+1.851	.004	<.001	3	2
LUNG_SCLC	AIFM2 →	-0.242	-1.818	<.001	<.001	3	2
LUNG_SCLC	CST11 →	+0.277	+1.807	.009	<.001	3	2
OVARY	FRK →	-0.155	-1.952	.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CLEC3B by Vascular wound healing activity — BREAST

Explore this box plot interactively →