Regulation of wound healing

Across TCGA cell cohorts, RNA activity of the Regulation of wound healing pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRAF2, DYNLRB1, and PNKD, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TRAF2 grouped by Regulation of wound healing-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	TRAF2 →	+1.053	+0.216	.002	.007	3	4
LARGE_INTESTINE	DYNLRB1 →	+0.871	+0.203	.002	<.001	3	3
KIDNEY	PNKD →	+0.653	+0.956	.006	.003	3	3
KIDNEY	GABARAPL2 →	+0.818	+1.213	.004	.001	3	3
BREAST	STXBP4 →	+0.533	+0.293	.004	.009	3	3
LIVER	PSMD10 →	+0.805	+0.232	.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TRAF2 by Regulation of wound healing activity — URINARY_TRACT

Explore this box plot interactively →