Regulation of wound healing

Across TCGA cell cohorts, RNA activity of the Regulation of wound healing pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRAPPC10, TRPC3, and PLRG1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TRAPPC10 grouped by Regulation of wound healing-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	TRAPPC10 →	-0.301	-0.079	<.001	.003	3	6
PANCREAS	TRPC3 →	+0.158	+0.097	<.001	.005	3	5
CNS	PLRG1 →	-0.272	-0.097	.004	.006	2	6
LUNG_NSCLC_LUSC	PAX8 →	+0.118	+0.162	.006	.002	3	5
SKIN	ACLY →	-0.291	-0.108	.002	<.001	3	5
LUNG_NSCLC_LUAD	OTX1 →	-0.110	-0.068	.008	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TRAPPC10 by Regulation of wound healing activity — SKIN

Explore this box plot interactively →