Uterus morphogenesis

Across TCGA patient cohorts, RNA activity of the Uterus morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PARP1, POGK, and YTHDC1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Uterus morphogenesis activity versus PARP1 in LUAD (Pearson r = 0.23).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	PARP1 →	+0.389	+0.127	<.001	<.001	3	8
HNSC	POGK →	+0.319	+0.093	<.001	<.001	3	8
HNSC	YTHDC1 →	+0.245	+0.104	.004	<.001	3	7
BRCA	CDC73 →	+0.265	+0.067	<.001	<.001	3	7
LSCC	DHX9 →	+0.247	+0.118	<.001	<.001	3	7
LSCC	KDM5B →	+0.406	+0.087	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061038 vs PARP1 — LUAD

Explore this scatter interactively →