Positive regulation of cartilage development

Across TCGA patient cohorts, RNA activity of the Positive regulation of cartilage development pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LOXL2, SPARC, and FN1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of cartilage development activity versus LOXL2 in OV (Pearson r = -0.03).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	LOXL2 →	+1.567	+0.649	<.001	.001	3	7
BRCA	SPARC →	+1.415	+0.824	<.001	<.001	3	7
BRCA	FN1 →	+1.342	+0.630	<.001	.002	3	7
OV	TCF4 →	+0.991	+0.669	<.001	.002	3	7
BRCA	FERMT2 →	+0.924	+0.606	<.001	<.001	3	7
LSCC	PNMA8A →	+0.904	+0.182	.001	.007	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061036 vs LOXL2 — OV

Explore this scatter interactively →