Positive regulation of cartilage development

Across TCGA cell cohorts, RNA activity of the Positive regulation of cartilage development pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CTRL, RNF10, and OSBP, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CTRL grouped by Positive regulation of cartilage development-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	CTRL →	+0.485	+1.422	.003	<.001	3	4
BLOOD_Leukemia	RNF10 →	+0.550	+1.191	.001	<.001	3	4
BREAST	OSBP →	+0.482	+0.399	.006	.005	3	3
STOMACH	AGFG2 →	-1.358	-1.211	.001	<.001	3	3
KIDNEY	NDFIP2 →	-1.011	-1.274	.002	.001	3	3
STOMACH	MAP4K5 →	+0.921	+1.313	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CTRL by Positive regulation of cartilage development activity — KIDNEY

Explore this box plot interactively →