Positive regulation of cartilage development

Across TCGA cell cohorts, RNA activity of the Positive regulation of cartilage development pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ETFB, BLOC1S3, and PPP4R4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of cartilage development activity versus ETFB in LARGE_INTESTINE (Pearson r = 0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ETFB →	+1.233	+0.488	.001	<.001	3	4
KIDNEY	BLOC1S3 →	+0.971	+0.216	.007	.005	3	4
KIDNEY	PPP4R4 →	-1.162	-0.251	.006	<.001	3	3
LARGE_INTESTINE	SACS →	-1.930	-0.507	.007	.002	3	3
LARGE_INTESTINE	KLK1 →	+4.358	+0.509	.005	.006	3	3
LARGE_INTESTINE	ENHO →	-1.188	-0.539	.005	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061036 vs ETFB — LARGE_INTESTINE

Explore this scatter interactively →