Cardiac muscle tissue regeneration

Across TCGA patient cohorts, RNA activity of the Cardiac muscle tissue regeneration pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HCN3, AHNAK, and MCF2L, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cardiac muscle tissue regeneration activity versus HCN3 in LUAD (Pearson r = -0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	HCN3 →	-0.417	-0.155	.007	.007	3	4
LUAD	AHNAK →	+0.618	+0.228	.002	.001	3	3
LUAD	MCF2L →	-0.624	-0.177	<.001	.004	3	3
LUAD	BPIFA2 →	-1.123	-0.197	.002	<.001	3	3
GBM	YAP1 →	+0.618	+0.309	<.001	<.001	3	3
LUAD	CSF2 →	+1.123	+0.211	.002	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061026 vs HCN3 — LUAD

Explore this scatter interactively →