Cardiac muscle tissue regeneration

Across TCGA cell cohorts, RNA activity of the Cardiac muscle tissue regeneration pathway is significantly associated with the shRNA dependency of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OLIG3, ARHGEF15, and DPY30, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, OLIG3 grouped by Cardiac muscle tissue regeneration-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	OLIG3 →	-0.210	-0.208	.004	.007	3	6
LARGE_INTESTINE	ARHGEF15 →	-0.233	-0.248	.003	<.001	3	5
BREAST	DPY30 →	-0.223	-0.184	.001	.001	3	4
BREAST	SLIT1 →	-0.180	-0.238	.005	<.001	3	4
OESOPHAGUS	MLKL →	+0.171	+0.254	.003	.006	3	4
OESOPHAGUS	GPAA1 →	-0.096	-0.349	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

OLIG3 by Cardiac muscle tissue regeneration activity — SOFT_TISSUE

Explore this box plot interactively →