Regulation of mRNA catabolic process

Across TCGA cell cohorts, RNA activity of the Regulation of mRNA catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NPM3, EIF2S1, and EIF5A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of mRNA catabolic process activity versus NPM3 in SKIN (Pearson r = 0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	NPM3 →	+0.782	+0.142	.002	.002	3	5
KIDNEY	EIF2S1 →	+0.718	+0.189	.007	.008	3	5
OVARY	EIF5A →	+0.786	+0.138	.003	.002	3	5
LUNG_SCLC	CAP2 →	+1.910	+0.145	.007	.001	3	5
OESOPHAGUS	STOML2 →	+0.651	+0.199	.009	<.001	3	5
OVARY	EIF4A1 →	+0.753	+0.117	.002	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061013 vs NPM3 — SKIN

Explore this scatter interactively →