Cell differentiation involved in kidney development

Across TCGA cell cohorts, RNA activity of the Cell differentiation involved in kidney development pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BASP1, CATSPER1, and BDNF, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cell differentiation involved in kidney development activity versus BASP1 in LUNG_NSCLC_LUAD (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	BASP1 →	+4.059	+0.437	<.001	.002	3	8
BREAST	CATSPER1 →	+1.211	+0.466	.003	<.001	3	7
BREAST	BDNF →	+2.331	+0.413	.001	<.001	3	7
OVARY	NMT2 →	+1.643	+0.421	<.001	<.001	3	7
BREAST	PODXL →	+1.649	+0.270	.001	<.001	3	6
OVARY	HCFC1R1 →	+1.148	+0.234	.003	.008	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061005 vs BASP1 — LUNG_NSCLC_LUAD

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