Positive regulation of dendritic spine morphogenesis

Across TCGA patient cohorts, RNA activity of the Positive regulation of dendritic spine morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are WDR36, MARCKSL1_S22, and AAAS, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of dendritic spine morphogenesis activity versus WDR36 in LSCC (Pearson r = 0.24).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	WDR36 →	+0.347	+0.052	<.001	<.001	3	5
COAD	MARCKSL1_S22 →	+0.293	+0.017	.003	.005	3	5
LSCC	AAAS →	+0.139	+0.051	<.001	<.001	3	5
LSCC	TEX10 →	+0.337	+0.051	<.001	<.001	3	4
LSCC	LAS1L →	+0.330	+0.044	<.001	<.001	3	4
LSCC	RCSD1_S298 →	-0.785	-0.058	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061003 vs WDR36 — LSCC

Explore this scatter interactively →