Positive regulation of dendritic spine morphogenesis

Across TCGA cell cohorts, RNA activity of the Positive regulation of dendritic spine morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CAPN7, SLC6A8, and GM2A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CAPN7 grouped by Positive regulation of dendritic spine morphogenesis-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CAPN7 →	+0.575	+0.290	.005	.001	3	5
STOMACH	SLC6A8 →	+2.349	+0.169	.001	.008	3	4
BLOOD_Lymphoma	GM2A →	-2.239	-0.334	.001	.007	3	3
BLOOD_Lymphoma	ZNF860 →	-3.222	-0.387	<.001	.007	3	3
KIDNEY	HOXA3 →	-1.354	-0.319	.002	.002	3	3
LUNG_NSCLC_LUAD	BMP2 →	-1.135	-0.201	.007	.002	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CAPN7 by Positive regulation of dendritic spine morphogenesis activity — BLOOD_Leukemia

Explore this box plot interactively →