Negative regulation of dendritic spine morphogenesis

Across TCGA patient cohorts, RNA activity of the Negative regulation of dendritic spine morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TUBA4A, GLS, and TIMM8A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of dendritic spine morphogenesis activity versus TUBA4A in GBM (Pearson r = 0.18).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TUBA4A →	+0.366	+0.061	.001	<.001	3	5
BRCA	GLS →	+0.583	+0.059	<.001	<.001	3	5
BRCA	TIMM8A →	+0.427	+0.051	<.001	.008	3	4
HNSC	TIPRL →	+0.176	+0.039	<.001	.004	3	4
BRCA	CLIC6_S322 →	-0.991	-0.061	<.001	<.001	3	4
LUAD	S100A1 →	+0.921	+0.041	.008	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061002 vs TUBA4A — GBM

Explore this scatter interactively →