Regulation of dendritic spine morphogenesis

Across TCGA patient cohorts, RNA activity of the Regulation of dendritic spine morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SPCS2, STT3B, and RAB11FIP5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of dendritic spine morphogenesis activity versus SPCS2 in LSCC (Pearson r = -0.25).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SPCS2 →	-0.516	-0.039	<.001	<.001	3	5
PDAC	STT3B →	-0.404	-0.031	.002	.001	3	5
GBM	RAB11FIP5 →	+0.320	+0.075	<.001	<.001	3	5
LSCC	GMPPB →	-0.339	-0.038	.001	.002	3	5
BRCA	COPB2_T828 →	-0.373	-0.022	.004	.001	3	4
BRCA	COX5B →	-0.290	-0.019	<.001	.002	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061001 vs SPCS2 — LSCC

Explore this scatter interactively →