Regulation of dendritic spine morphogenesis

Across TCGA cell cohorts, RNA activity of the Regulation of dendritic spine morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LETM2, ELP5, and VAMP3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of dendritic spine morphogenesis activity versus LETM2 in PANCREAS (Pearson r = 0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	LETM2 →	+2.394	+0.278	.009	<.001	2	5
BREAST	ELP5 →	+1.250	+0.263	.005	.001	3	4
BREAST	VAMP3 →	+0.756	+0.212	.007	.006	3	4
BLOOD_Leukemia	PPWD1 →	+0.489	+0.135	.003	.003	3	4
LUNG_NSCLC_LUAD	MED20 →	+0.646	+0.209	<.001	<.001	3	4
BLOOD_Leukemia	MYH10 →	+2.091	+0.149	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061001 vs LETM2 — PANCREAS

Explore this scatter interactively →