Negative regulation of dendritic spine development

Across TCGA patient cohorts, RNA activity of the Negative regulation of dendritic spine development pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SPN_S368, UPF3B, and APBB1IP, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of dendritic spine development activity versus SPN_S368 in LSCC (Pearson r = -0.16).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SPN_S368 →	-0.678	-0.049	<.001	<.001	3	5
UCEC	UPF3B →	+0.162	+0.065	.003	<.001	3	5
CCRCC	APBB1IP →	-0.399	-0.041	.002	.002	3	5
BRCA	FAM114A2 →	-0.246	-0.036	.002	.006	3	5
BRCA	PHF6 →	+0.436	+0.047	<.001	<.001	3	5
PDAC	PFDN6 →	+0.213	+0.028	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061000 vs SPN_S368 — LSCC

Explore this scatter interactively →