Negative regulation of dendritic spine development

Across TCGA patient cohorts, RNA activity of the Negative regulation of dendritic spine development pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC16A6, NUDT1, and ACTR3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of dendritic spine development activity versus SLC16A6 in BRCA (Pearson r = -0.01).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SLC16A6 →	+1.011	+0.405	.005	.001	3	5
LUAD	NUDT1 →	-0.431	-0.123	<.001	.007	3	4
BRCA	ACTR3 →	-0.333	-0.328	.001	.001	3	4
CCRCC	PBX1 →	+0.749	+0.288	.002	.002	3	4
LUAD	IMPDH1 →	-0.472	-0.151	.004	.002	3	4
HNSC	CREBRF →	+0.651	+0.707	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061000 vs SLC16A6 — BRCA

Explore this scatter interactively →