Negative regulation of dendritic spine development

Across TCGA cell cohorts, RNA activity of the Negative regulation of dendritic spine development pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AFTPH, GNRH1, and NECAP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of dendritic spine development activity versus AFTPH in UPPER_AERODIGESTIVE_TRACT (Pearson r = -0.77).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	AFTPH →	-0.856	-1.272	.001	<.001	3	5
URINARY_TRACT	GNRH1 →	+0.810	+1.489	<.001	<.001	3	4
BREAST	NECAP1 →	-0.935	-0.702	<.001	.002	3	4
LARGE_INTESTINE	PPIF →	-0.723	-1.101	.007	.001	3	4
OVARY	THBS1 →	-3.022	-0.871	.004	.009	3	4
SOFT_TISSUE	FYCO1 →	-1.275	-1.757	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061000 vs AFTPH — UPPER_AERODIGESTIVE_TRACT

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