Positive regulation of dendritic spine development

Across TCGA patient cohorts, RNA activity of the Positive regulation of dendritic spine development pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPL23A, SEC24A, and UCHL1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of dendritic spine development activity versus RPL23A in GBM (Pearson r = -0.24).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RPL23A →	-0.274	-0.042	.004	<.001	2	5
LSCC	SEC24A →	-0.275	-0.028	.001	.005	3	4
LSCC	UCHL1 →	+1.064	+0.031	<.001	.003	3	4
LSCC	MAP1B_S614 →	+1.344	+0.033	<.001	<.001	3	4
GBM	TAMALIN_S94 →	+0.561	+0.044	<.001	<.001	3	4
GBM	FAM219A_S72 →	+0.561	+0.050	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060999 vs RPL23A — GBM

Explore this scatter interactively →