Positive regulation of dendritic spine development

Across TCGA patient cohorts, RNA activity of the Positive regulation of dendritic spine development pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SPIN1_S199, JMJD7, and JPT2_S97, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of dendritic spine development activity versus SPIN1_S199 in OV (Pearson r = -0.43).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SPIN1_S199 →	-0.486	-0.326	.005	.005	2	4
BRCA	JMJD7 →	+0.447	+0.313	.004	.002	3	3
BRCA	JPT2_S97 →	+0.496	+0.191	.001	.006	3	3
LUAD	CCT4_S236 →	-0.422	-0.795	<.001	<.001	3	3
UCEC	AP1S3 →	+0.601	+0.712	<.001	.002	3	3
UCEC	MTDH_S308 →	+0.402	+0.496	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060999 vs SPIN1_S199 — OV

Explore this scatter interactively →