Positive regulation of dendritic spine development

Across TCGA cell cohorts, RNA activity of the Positive regulation of dendritic spine development pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC6A8, TADA1, and CWC22, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC6A8 grouped by Positive regulation of dendritic spine development-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	SLC6A8 →	+1.321	+0.278	.006	.007	2	7
BONE	TADA1 →	-0.817	-0.291	.001	.003	3	4
KIDNEY	CWC22 →	-0.632	-0.312	<.001	.004	3	3
KIDNEY	HDHD5 →	-0.841	-0.253	.001	.009	3	3
OVARY	CTSG →	+0.248	+0.193	.004	.004	3	3
OVARY	MECR →	-0.469	-0.236	.004	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC6A8 by Positive regulation of dendritic spine development activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →