Positive regulation of dendritic spine development

Across TCGA cell cohorts, RNA activity of the Positive regulation of dendritic spine development pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PDLIM7, CAPRIN2, and SLC30A1, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of dendritic spine development activity versus PDLIM7 in UPPER_AERODIGESTIVE_TRACT (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	PDLIM7 →	+1.753	+0.120	<.001	<.001	3	11
BONE	CAPRIN2 →	+1.092	+0.095	.009	.002	3	11
BONE	SLC30A1 →	+1.179	+0.100	.001	<.001	3	10
BONE	GALNT2 →	+1.577	+0.075	<.001	.002	3	10
BONE	GALNT10 →	+2.022	+0.078	<.001	.002	3	10
BONE	LAMC1 →	+1.763	+0.070	.002	.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060999 vs PDLIM7 — UPPER_AERODIGESTIVE_TRACT

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