Positive regulation of dendritic spine development

Across TCGA cell cohorts, RNA activity of the Positive regulation of dendritic spine development pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GMNN, DBN1, and C17orf75, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of dendritic spine development activity versus GMNN in OVARY (Pearson r = 0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	GMNN →	+1.071	+0.161	.009	.005	3	6
BLOOD_Leukemia	DBN1 →	+1.142	+0.190	<.001	<.001	3	6
LUNG_NSCLC_LUSC	C17orf75 →	+1.033	+0.250	.002	<.001	3	5
BLOOD_Leukemia	RFC5 →	+0.717	+0.155	<.001	.001	3	5
BLOOD_Leukemia	HMGB2 →	+0.668	+0.167	<.001	<.001	3	5
BLOOD_Leukemia	HPRT1 →	+0.592	+0.177	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060999 vs GMNN — OVARY

Explore this scatter interactively →