Regulation of dendritic spine development

Across TCGA patient cohorts, RNA activity of the Regulation of dendritic spine development pathway is significantly associated with the RNA expression of multiple genes, with the ACC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF236, KIAA1109, and BPTF, each associated with the pathway in up to 33 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of dendritic spine development activity versus ZNF236 in ACC (Pearson r = 0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ACC	ZNF236 →	+0.796	+0.029	<.001	<.001	3	33
THYM	KIAA1109 →	+1.307	+0.033	<.001	<.001	3	33
KIRP	BPTF →	+0.946	+0.029	<.001	<.001	3	33
OV	HECTD4 →	+0.855	+0.038	<.001	<.001	3	33
THYM	NR2C2 →	+1.140	+0.035	<.001	<.001	3	33
UVM	GPATCH8 →	+0.994	+0.029	<.001	<.001	3	33

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060998 vs ZNF236 — ACC

Explore this scatter interactively →