Regulation of dendritic spine development

Across TCGA patient cohorts, RNA activity of the Regulation of dendritic spine development pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are KIF1B_S1487, AP1G1, and SEC24A, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of dendritic spine development activity versus KIF1B_S1487 in LSCC (Pearson r = -0.16).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	KIF1B_S1487 →	-0.418	-0.029	.001	<.001	3	6
UCEC	AP1G1 →	-0.202	-0.057	.002	<.001	3	5
CCRCC	SEC24A →	-0.205	-0.021	<.001	<.001	3	5
UCEC	COG1 →	-0.229	-0.043	.001	.001	3	5
CCRCC	SLC35E1 →	-0.197	-0.017	.002	.002	3	5
LSCC	UCHL1 →	+0.989	+0.030	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060998 vs KIF1B_S1487 — LSCC

Explore this scatter interactively →