Regulation of dendritic spine development

Across TCGA patient cohorts, RNA activity of the Regulation of dendritic spine development pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KIF1A, ZNF440, and CCDC130, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of dendritic spine development activity versus KIF1A in UCEC (Pearson r = 0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	KIF1A →	+1.544	+0.544	<.001	.002	3	4
UCEC	ZNF440 →	-0.585	-0.750	.001	<.001	3	3
BRCA	CCDC130 →	-0.547	-0.260	.001	.006	3	3
BRCA	ARHGAP22 →	-0.436	-0.266	<.001	<.001	3	3
BRCA	MYL6P5 →	-1.346	-0.347	<.001	<.001	3	3
BRCA	MKRN9P →	-0.238	-0.244	.009	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060998 vs KIF1A — UCEC

Explore this scatter interactively →