Regulation of dendritic spine development

Across TCGA cell cohorts, RNA activity of the Regulation of dendritic spine development pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MSI1, KCNAB2, and IFT81, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MSI1 grouped by Regulation of dendritic spine development-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	MSI1 →	+1.085	+0.490	<.001	.002	3	4
OESOPHAGUS	KCNAB2 →	-1.600	-0.292	<.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	IFT81 →	-1.282	-0.244	<.001	<.001	3	3
BONE	KAT14 →	-0.752	-0.185	.006	.007	3	3
BONE	TOMM20 →	-1.199	-0.222	.001	<.001	3	3
BLOOD_Leukemia	NOS3 →	+2.029	+0.241	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MSI1 by Regulation of dendritic spine development activity — URINARY_TRACT

Explore this box plot interactively →