Regulation of dendritic spine development

Across TCGA cell cohorts, RNA activity of the Regulation of dendritic spine development pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TSPO, MAPK10, and SLC16A10, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of dendritic spine development activity versus TSPO in BLOOD_Leukemia (Pearson r = -0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TSPO →	-2.625	-0.140	.004	.003	3	5
KIDNEY	MAPK10 →	+1.447	+0.158	.008	.006	3	5
STOMACH	SLC16A10 →	+2.168	+0.298	<.001	<.001	3	4
BLOOD_Leukemia	QSOX1 →	-1.625	-0.146	<.001	.003	3	4
BLOOD_Leukemia	RPAIN →	+0.785	+0.146	<.001	.002	3	4
SKIN	RFC5 →	+0.595	+0.161	.007	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060998 vs TSPO — BLOOD_Leukemia

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