Dendritic spine morphogenesis

Across TCGA patient cohorts, RNA activity of the Dendritic spine morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GIMAP7, EHD4, and CD33, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Dendritic spine morphogenesis activity versus GIMAP7 in LSCC (Pearson r = 0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	GIMAP7 →	+0.998	+0.771	<.001	.001	3	4
OV	EHD4 →	+0.477	+0.399	<.001	<.001	3	4
LSCC	CD33 →	+0.573	+0.854	<.001	<.001	3	4
LSCC	SDC4 →	+0.836	+0.781	<.001	<.001	2	5
LSCC	VENTX →	+0.469	+0.803	.008	.004	3	4
LUAD	CX3CR1 →	+0.681	+0.732	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060997 vs GIMAP7 — LSCC

Explore this scatter interactively →