Dendritic spine development

Across TCGA patient cohorts, RNA activity of the Dendritic spine development pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CEP170, UBE2J1, and PSMB10_S230, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Dendritic spine development activity versus CEP170 in GBM (Pearson r = 0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CEP170 →	+0.257	+0.051	<.001	<.001	3	6
PDAC	UBE2J1 →	-0.281	-0.022	.006	.005	3	5
LUAD	PSMB10_S230 →	-0.583	-0.030	.003	<.001	3	5
LSCC	MAP1B_S891 →	+1.237	+0.043	.001	<.001	3	5
GBM	SND1_S645 →	-0.691	-0.044	.003	.007	3	4
PDAC	SPIN1 →	+0.352	+0.022	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060996 vs CEP170 — GBM

Explore this scatter interactively →