Dendritic spine development

Across TCGA cell cohorts, RNA activity of the Dendritic spine development pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NYAP1, CCDC30, and ANKRD13B, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NYAP1 grouped by Dendritic spine development-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	NYAP1 →	-0.415	-0.436	.006	.005	3	3
LUNG_NSCLC_LUAD	CCDC30 →	-0.414	-0.591	.004	.002	3	3
SOFT_TISSUE	ANKRD13B →	-1.444	-1.152	.004	.003	3	3
BLOOD_Leukemia	DAP →	+1.086	+1.572	<.001	<.001	3	3
OVARY	TMEM59 →	+1.136	+0.719	<.001	.003	3	3
BLOOD_Leukemia	ARPC1B →	+0.943	+1.108	.008	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NYAP1 by Dendritic spine development activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →