Kidney morphogenesis

Across TCGA patient cohorts, RNA activity of the Kidney morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GGA3_S159, GMIP, and LTBP3, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Kidney morphogenesis activity versus GGA3_S159 in PDAC (Pearson r = -0.10).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	GGA3_S159 →	-0.284	-0.028	<.001	<.001	3	7
LSCC	GMIP →	-0.218	-0.025	<.001	<.001	3	7
HNSC	LTBP3 →	+0.463	+0.034	<.001	<.001	3	7
PDAC	DDX21_S89 →	-0.903	-0.031	<.001	<.001	3	6
HNSC	FARP1 →	+0.361	+0.036	<.001	<.001	3	6
PDAC	GPATCH4 →	-0.728	-0.041	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060993 vs GGA3_S159 — PDAC

Explore this scatter interactively →