Kidney morphogenesis

Across TCGA patient cohorts, RNA activity of the Kidney morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KANK2, ARMC9, and MMP16, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Kidney morphogenesis activity versus KANK2 in LSCC (Pearson r = 0.08).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	KANK2 →	+0.470	+0.252	<.001	.001	3	8
BRCA	ARMC9 →	+0.568	+0.611	.001	.002	3	6
BRCA	MMP16 →	+0.886	+0.633	<.001	.001	3	6
BRCA	ARHGEF40 →	+0.486	+0.520	<.001	<.001	3	6
COAD	MSRB3 →	+0.682	+0.624	.006	.005	3	6
LSCC	PRKD1 →	+0.555	+0.298	.001	.003	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060993 vs KANK2 — LSCC

Explore this scatter interactively →