Kidney morphogenesis

Across TCGA cell cohorts, RNA activity of the Kidney morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IER5, PROM2, and TACSTD2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Kidney morphogenesis activity versus IER5 in LARGE_INTESTINE (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	IER5 →	+0.964	+1.300	.008	.004	1	8
PANCREAS	PROM2 →	+4.805	+1.684	<.001	<.001	3	5
OVARY	TACSTD2 →	+5.982	+1.283	<.001	<.001	3	5
LUNG_NSCLC_LUAD	GALNT6 →	+2.546	+1.043	.005	.007	3	5
PANCREAS	PTAFR →	+2.618	+1.736	<.001	<.001	3	5
OVARY	MAPK13 →	+1.952	+1.180	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060993 vs IER5 — LARGE_INTESTINE

Explore this scatter interactively →