Response to fungicide

Across TCGA patient cohorts, RNA activity of the Response to fungicide pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are REXO4, RPL4_S295, and RRP36_S73, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to fungicide activity versus REXO4 in COAD (Pearson r = 0.27).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	REXO4 →	+0.335	+0.061	.004	.001	3	5
LUAD	RPL4_S295 →	+1.422	+0.058	<.001	<.001	3	5
UCEC	RRP36_S73 →	+0.691	+0.066	<.001	<.001	3	5
LUAD	KIF13B_S1381 →	-0.746	-0.070	.005	.006	3	5
LUAD	TNKS1BP1 →	-0.180	-0.049	<.001	<.001	3	5
PDAC	BCAS1_S552 →	-1.212	-0.052	.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060992 vs REXO4 — COAD

Explore this scatter interactively →