Response to fungicide

Across TCGA cell cohorts, RNA activity of the Response to fungicide pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CNOT2, CEPT1, and KTI12, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CNOT2 grouped by Response to fungicide-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	CNOT2 →	-0.568	-1.380	.001	.001	2	5
KIDNEY	CEPT1 →	+0.698	+1.087	.001	.003	3	3
LUNG_NSCLC_LUAD	KTI12 →	+0.750	+1.049	.009	<.001	2	4
OVARY	LIFR →	-1.133	-1.202	.004	<.001	3	3
SOFT_TISSUE	RSPH14 →	+0.893	+1.482	.006	.001	3	3
LUNG_NSCLC_LUSC	SP6 →	-1.068	-1.279	.005	.009	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CNOT2 by Response to fungicide activity — STOMACH

Explore this box plot interactively →