Endocrine hormone secretion

Across TCGA patient cohorts, RNA activity of the Endocrine hormone secretion pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are BGN, MRTO4, and SPARCL1_S295, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endocrine hormone secretion activity versus BGN in CCRCC (Pearson r = 0.27).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	BGN →	+0.736	+0.056	<.001	<.001	3	9
BRCA	MRTO4 →	-0.379	-0.051	<.001	<.001	3	9
BRCA	SPARCL1_S295 →	+0.784	+0.030	<.001	<.001	3	8
LSCC	XRCC6_T455 →	-0.691	-0.050	<.001	<.001	3	8
UCEC	CSE1L →	-0.379	-0.050	<.001	<.001	3	8
BRCA	ANG →	+0.571	+0.030	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060986 vs BGN — CCRCC

Explore this scatter interactively →